Intracoronary Administration of Drugs in Clinical Practice

Intracoronary administration of drugs allows to achieve the fastest possible effect in interventional cardiology. This avoid all biological filters body and required concentration active substance at injection site. Also, given local action, systemic side effects are nearly absent.
 The aim. To study literature data leading countries world field intracoronary drug administration. analyze experience different centers on use various medications treatment phenomenon distal microembolization.
 Results. One first administered was streptokinase for acute myocardial infarction. After that, it became clear that this method delivering is can be used. With beginning coronary syndromes by stenting, one complications arose form no-reflow. At same time, realizing a problem, they began possibility treat phenomenon. main advantage quick response Today, choice no-reflow verapamil, adenosine, nitroprusside, adrenaline. On other hand, probably most common nitroglycerin. It used as vasodilator event spasm arteries. Subsequently, has been recommended deliver via microcatheter or aspiration catheter even more selective area affected vessel, also minimizes loss due reflux into aortic sinuses while usinga guiding catheter. Work underway insulin syndrome order reduce damage very promising introduction stem cells directlyinto myocardium through regenerate after heart attack.
 Conclusions. maximum shortest time. many way, starting from microembolization ending with regeneration